The ntAES_XTS IP Core is fully compliant with AES-XTS algorithm standardized at NIST SP800-38E and IEEE 1619-2007 recommendations targeting disk encryption applications at sector (data unit) addressable level. It is also known as a tweakable block cipher where the encryption process is controlled by the tweak a 128-bit value that is generated from the actual logical position of the data unit on the disk. This way identical data units stored at different places will result in different encrypted data thus addressing copy-and-paste attacks. Each data unit size is at least 128-bits. In addition each data unit size can be either an integral or non-integral number of 128-bit blocks. In case where the data unit size is not divisible with 128 then the ciphertext stealing procedure is used to enable correct encryption of the last block. Due to its highly parameterized and scalable architecture the users can trade off logic resources and performance in order to achieve optimum match with their application requirement. The implementation is low on latency, high speed with a simple interface for easy integration in SoC applications.